Omeprazole: effects on oxidative drug metabolism.
نویسندگان
چکیده
منابع مشابه
Drug interaction: Omeprazole and Phenprocoumon
BACKGROUND Oral anticoagulants like the coumarin derivatives are characterised by a particularly narrow therapeutic range. Any interfering co-medication can pose a challenge to establishing a stable anticoagulant dosage regimen and thus present a serious risk for the patient. Here we describe two cases of patients on anticoagulant therapy that suggest possible drug interactions between phenproc...
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The thienopyridine derivative ticlopidine (TCL) is an inhibitor of adenosine diphosphate-induced platelet aggregation. Combination therapy with a thienopyridine derivative and aspirin is standard after coronary stenting, although more hemorrhagic complications occur with the combination therapy than with aspirin alone. A proton pump inhibitor (PPI) is required for prevention or treatment of upp...
متن کاملEffects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans.
BACKGROUND AND PURPOSE A triple therapy with omeprazole, amoxicillin (INN, amoxicilline), and clarithromycin is widely used for the eradication of Helicobacter pylori. Omeprazole and clarithromycin are metabolized by CYP2C19 and CYP3A4. This study aimed to elucidate whether clarithromycin affects the metabolism of omeprazole. METHODS After administration of placebo or 400 mg clarithromycin tw...
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When dormant sugar pine (Pinus lambertiana L.) seeds were imbibed at 5 degrees C, they showed a rapid increase in O(2) uptake, ATP level, and moisture content during the first 4 days. This was followed by a plateau phase until 60 days, after which a second significant increase in all three features occurred as dormancy was broken. During the plateau phase, conventional CN-sensitive respiration ...
متن کاملOmeprazole induces altered bile acid metabolism.
BACKGROUND It has been reported that the acidity of gastric contents could be an important factor in regulating jejunal flora. AIMS To investigate the effects of omeprazole induced changes in gastric pH on jejunal flora and bile acid metabolism. METHODS Twenty one patients with gastric ulcer and 19 healthy volunteers were studied. Deconjugation of bile acids was detected using a bile acid b...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1984
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1984.tb02452.x